Did you know that Bee venom (Apis mellifera) has been used for the treatment of various chronic diseases, such as chronic inflammatory arthritis and chronic liver disease? Heck no I didn't. You learn something every day.
Study Summary:
Alcohol consumption increases apoptosis of hepatocytes. Death of hepatocytes is a characteristic feature of chronic liver disease for various causes. Bee venom (Apis mellifera) has been traditionally used for the treatment of various chronic diseases, such as chronic inflammatory arthritis and chronic liver disease. However, the precise mechanism for bee venom in chronic liver disease is not still cleared. To assess the effects of bee venom in chronic liver disease, we investigated the potential role of the bee venom in the ethanol-induced hepatocyte apoptosis. Bee venom treatment inhibited the apoptotic cell morphology and increased the cell viability in ethanol-induced hepatocyte apoptosis. With ethanol treatment, bee venom-treated hepatocytes increased activity of Bcl-2 and Bcl-xL, reduced activity of Bax, Caspase and PARP. In conclusion, bee venom treatment in ethanol-induced hepatocyte apoptosis occurred through the regulation of Bcl family with subsequent inactivation of the Caspase and PARP. These results suggest that bee venom could be an effective agent to reduce ethanol-induced hepatocyte apoptosis.
Reference
Basic Clin Pharmacol Toxicol. 2010 Mar 4. [Epub ahead of print]
The Protective Effect of Bee Venom against Ethanol-Induced Hepatic Injury via Regulation of the Mitochondria-Related Apoptotic Pathway.
Kim KH, Kum YS, Park YY, Park JH, Kim SJ, Lee WR, Lee KG, Han SM, Park KK.
Department of Pathology, College of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
